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Breast: Adjuvant chemotherapy and genomic assays

Published 26 October 2026 · a new question every day · browse the archive

BreastAdjuvant chemotherapy and genomic assays

A 62-year-old postmenopausal woman has had breast-conserving surgery for a 19 mm, grade 2, strongly ER-positive, HER2-negative invasive ductal carcinoma with negative sentinel nodes (pN0). A 21-gene recurrence score (Oncotype DX) returns a value of 17. She is fit and asks whether she needs chemotherapy in addition to endocrine therapy. What is the most appropriate recommendation?

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