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Gynaecology: Cervix — image-guided adaptive brachytherapy outcomes (EMBRACE-I)

Free question published 29 September 2026

GynaecologyCervix — image-guided adaptive brachytherapy outcomes (EMBRACE-I)

A regional gynae-oncology MDT is updating its patient information leaflet on radical chemoradiotherapy for locally advanced cervical cancer. A trainee is asked to summarise the local control achievable with modern MRI-guided adaptive brachytherapy, drawing on the prospective multicentre EMBRACE-I cohort. Which figure most accurately reflects the 5-year local control reported in that study?

  1. AApproximately 85% 5-year local control
  2. BApproximately 92% 5-year local control
  3. CApproximately 99% 5-year local control
  4. DApproximately 65% 5-year local control
  5. EApproximately 75% 5-year local control

Why B is correct

EMBRACE-I, a prospective multicentre cohort of MRI-guided adaptive brachytherapy after chemoradiotherapy, reported an actuarial overall 5-year local control of 92% (95% CI 90-93). This benchmark underpins the emphasis on high-quality image-guided brachytherapy as an essential component of definitive treatment.

And why the others are not

  • AIncorrect. 85% is below the reported figure; EMBRACE-I achieved higher local control.
  • CIncorrect. 99% overstates the result; the complete remission rate was 98% but actuarial 5-year local control was 92%.
  • DIncorrect. 65% understates the local control achievable with modern image-guided adaptive brachytherapy.
  • EIncorrect. 75% reflects older 2D brachytherapy era results, not the EMBRACE-I image-guided benchmark.

Source EMBRACE-I — MRI-guided adaptive brachytherapy in locally advanced cervical cancer — Potter R, Tanderup K, Schmid MP, et al. MRI-guided adaptive brachytherapy in locally advanced cervical cancer (EMBRACE-I): a multicentre prospective cohort study. Lancet Oncology, 2021.

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